{"id":10654,"date":"2025-11-26T11:45:22","date_gmt":"2025-11-26T10:45:22","guid":{"rendered":"https:\/\/www.burg-halle.de\/gast\/?p=10654"},"modified":"2025-11-26T11:45:38","modified_gmt":"2025-11-26T10:45:38","slug":"ya-ferm","status":"publish","type":"post","link":"https:\/\/www.burg-halle.de\/gast\/projects\/microbial-factories\/ya-ferm\/","title":{"rendered":"Ya-Ferm"},"content":{"rendered":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class='white' style='background:rgba(0,0,0,0); border:solid 0px rgba(0,0,0,0); border-radius:0px; padding:0px 0px 0px 0px;'>\n<div id='slider_1222' class='owl-carousel sa_owl_theme owl-pagination-true autohide-arrows' data-slider-id='slider_1222' style='visibility:hidden;'>\n<div id='slider_1222_slide01' class='sa_hover_container' style='padding:5% 5%; margin:0px 0%; '><div class=\"container\"><iframe class=\"video\" src=\"https:\/\/player.vimeo.com\/video\/1140747748?autoplay=0&amp;loop=0&amp;autopause=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/div><\/div>\n<div id='slider_1222_slide02' class='sa_hover_container' style='padding:5% 5%; 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These raw materials are currently brought in on a large scale to meet the needs of the soap, food, and pharmaceutical industries. At the same time, Germany is one of the world\u2018s leading exporters of soap products \u2013 a paradoxical model from both an ecological and economic perspective. A significant share of the industry\u2019s demand could be met using regionally available resources. By applying the fungus Yarrowia lipolytica, we use biofermentation of municipal waste to produce high-quality intermediates \u2013 sustainable, cost-efficient, and independent of monocultures or deforestation.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-table alignright is-style-regular\"><table><tbody><tr><td class=\"has-text-align-left\" data-align=\"left\">student:<\/td><td>Lisa G\u00f6tel<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">project:<\/td><td><a href=\"https:\/\/www.burg-halle.de\/gast\/projects\/microbial-factories\/\">Microbial Factories<\/a><\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">year:<\/td><td>2025<\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<div class=\"container\">\n<div class=\"_df_book df-lite\" id=\"df_10667\"  _slug=\"ya-ferm\" data-title=\"ya-ferm\" wpoptions=\"true\" thumbtype=\"\" ><\/div><script class=\"df-shortcode-script\" nowprocket type=\"application\/javascript\">window.option_df_10667 = {\"outline\":[],\"backgroundColor\":\"#fffffff\",\"height\":\"800\",\"autoEnableOutline\":\"false\",\"autoEnableThumbnail\":\"false\",\"overwritePDFOutline\":\"false\",\"direction\":\"1\",\"pageSize\":\"0\",\"source\":\"https:\\\/\\\/www.burg-halle.de\\\/gast\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Plakat_LisaGotel_MicrobialFactories.pdf\",\"wpOptions\":\"true\"}; if(window.DFLIP && window.DFLIP.parseBooks){window.DFLIP.parseBooks();}<\/script>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<div style=\"height:802px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:43px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-3 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.34%\">\n<p class=\"subtitle\">The industrial production of soap in Germany still relies heavily on imported raw materials, particularly tropical oils. As an alternative, regional waste-to-resource strategies offer a promising path forward. This project proposes the use of <em>Yarrowia lipolytica<\/em>, a robust oleaginous yeast capable of producing lipids and other industrially relevant compounds via biofermentation.<br>The organic waste used in this model is municipal waste collected from private households. The residual liquids, often byproducts of food preparation and biomass breakdown, are rich in organic matter suitable for microbial cultivation.In Germany, liquid waste from municipal organic streams is handled through several channels: some is reintegrated into composting facilities, some directed to biogas production, and some processed in wastewater treatment plants, where residuals may eventually be incinerated. A portion may end up in landfills or be later leached from landfill sites by rainfall.<br>This limits their full potential, as the carbon-rich liquids are commonly diverted for one-time energy recovery. A circular approach\u2014if physically and economically viable\u2014could instead enable their reintegration into biological processes, aligning better with long-term sustainability goals.<br>Conventional biofabrication already plays a dominant role in global chemical production: 99% of the world\u2019s citric acid is made through fermentation using <em>Aspergillus niger<\/em>, a pathogenic mold. This compound appears everywhere\u2014beverages, detergents, skincare, and even pharmaceuticals\u2014demonstrating how microbial processes have long reached the mainstream of consumption. The use of microorganisms to generate ingredients is no longer niche; it is foundational to modern manufacturing.Unlike <em>A. niger<\/em>, <em>Y. lipolytica<\/em> is non-toxic, safe to handle, and does not require sterile conditions. It can metabolize a wide array of substrates\u2014including sugars, fats, glycerol, hydrocarbons, and agricultural residues\u2014 and produce saturated and unsaturated fatty acids, organic acids, polyols like<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.34%\">\n<p class=\"subtitle\">erythritol, aroma molecules, terpenes, lipases, and other biochemicals.Depending on the nutrient input, fermentation conditions (such as pH, oxygen saturation, and temperature) can be tuned to guide metabolic pathways and create specific products. This adaptability makes <em>Yarrowia<\/em> an ideal candidate for local, circular production systems that valorize waste and reduce dependence on monocultures or imported feedstocks.<br>The production process begins with the collection and separation of organic waste liquids. These are filtered and split into aqueous and lipid phases. Cultivation takes place on the aqueous fraction, with <em>Y. lipolytica<\/em> converting the available organics into microbial oil and secondary metabolites. The fermentation is optimized for yield, and products are harvested using mechanical in vivo separation methods\u2014streamlining recovery and eliminating post-process sterilization steps. Lipids are then extracted through solvents or cold pressing, purified, and directed toward downstream uses such as saponification, where they\u2019re mixed with alkali to form soap and glycerol. Additional compounds from the fermentation process\u2014such as aroma agents or acids\u2014can be incorporated into the final product, resulting in a fully microbial, waste-fed soap.<br>Beyond soap, <em>Yarrowia lipolytica<\/em> holds potential across numerous sectors: from biosurfactants and emulsifiers to biofuels and specialty chemicals. Its ability to metabolize various substrates allows it to transform what was once considered unusable waste into valuable product ingredients. This metabolic versatility is key to the flexibility of circular chemistry, where regional specificity and feedstock availability can shape production outcomes.<br>By integrating biotechnology with waste management, this process outlines a scalable, ecologically sound alternative to conventional manufacturing. It not only substitutes imported materials with local waste but also redefines the value chain\u2014from household waste to high-quality biochemicals.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\"><\/div>\n<\/div>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Ya-Ferm Raw materials for soap production \u2013 fermented from press water and oil Our goal is to reduce Germany\u2019s dependence on imported palm and coconut oil. These raw materials are currently brought in on a large scale to meet the needs of the soap, food, and pharmaceutical industries. At the same time, Germany is one &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.burg-halle.de\/gast\/projects\/microbial-factories\/ya-ferm\/\" class=\"more-link\"><span class=\"screen-reader-text\">\u201eYa-Ferm\u201c<\/span> weiterlesen<\/a><\/p>\n","protected":false},"author":8,"featured_media":10656,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[368],"tags":[],"coauthors":[358],"_links":{"self":[{"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/posts\/10654"}],"collection":[{"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/comments?post=10654"}],"version-history":[{"count":2,"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/posts\/10654\/revisions"}],"predecessor-version":[{"id":10669,"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/posts\/10654\/revisions\/10669"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/media\/10656"}],"wp:attachment":[{"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/media?parent=10654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/categories?post=10654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/tags?post=10654"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.burg-halle.de\/gast\/wp-json\/wp\/v2\/coauthors?post=10654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}